Its history can be related in its churches and monuments where all the cultures brought here by the major Strada Regina (Queen's Road) merge; this road has always been a precious link between the South of Italy via Milan-Como and Central-northern Europe.

Famous over the ages Domaso is known for its wine, a limited production of only 1200 bottles, and praised also by Plinio il Vecchio. Its culinary history of the famous “missoltini", fished in spring and in autumn and then salted, dried in the sun and compressed in wood barrels. Another typical dish is polenta, served with mushrooms, meats and local cheese (as the Semuda and the Robiola) or cooked with fused butter and cheese (the polenta uncia).