The museum consists of the following sections:

• Collectibles section, which includes a prehistoric collection, a collection of Greek vases, Egyptian one, the halls of bronzes, gems and coins.
• Section Prehistoric and Protohistoric: illustrates the evolutionary process that led to the appearance of the human race, presenting the archaeological materials discovered in the Como area.
• The Roman Section, where they are placed the remains of the Roman Como area.

On the ground floor of the museum can be found the Roman Lapidary and a room dedicated to the great mosaic floor from the Roman era discovered in Perti Street, Como.